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CHARACTERISTICS
ACTIVE HALF-LIFE 4-6 HOURS
CLASSIFICATION PDE5 INHIBITOR
DOSAGE MEN 50 MG/DAY
ACNE NO
WATER RETENTION NO
HBR POSSIBLE
HEPATOTOXICITY NO
AROMATIZATION NO
ACTIVE SUBSTANCE SILDENAFIL
FORM 10 PILLS X 50 MG
MANUFACTURER SUNRISE REMEDIES

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Description

Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

MALEGRA-50

Malegra-50, one of the generics of Viagra, is prescribed for the treatment of erectile dysfunction. It contains 50 mg of Sildenafil Citrate- an amount sufficient enough to treat the problem of erectile dysfunction. Despite being a prescription medicine, it can be bought easily on the internet without any written prescription by a physician. The drug starts to show effects after 30-45 minutes of intake and these effects last for about 3-4 hours. Malegra-50 is available in the forms of oral tablets only. The drug can cause serious drug interaction and side effects with certain drugs, so people having cardiovascular diseases are strongly contraindicated.

Malegra-50 is manufactured by Sunrise Remedies Private Limited. The company started its operations 15 years ago in the year 1995. It is an Indian based company located in Ahmadabad, Gujrat. The company deals in pharmaceuticals as well as herbal medications. Both ayurvedic and allopathic forms of drugs are available here in a variety of formulations including capsules, tablets, liquid and topical forms. It claims to be working as per the regulations and standards of W.H.O GMP.

HOW IT WORKS:

Sildenafil Citrate, Malegra’s active ingredient, is a potent inhibitor of phosphodiesterase Type 5 (PDE5) in the corpus cavernosum. By this inhibition, it helps to protect cyclic guanosine monophosphate(cGMP) from being metabolized. As nitric oxide (NO) levels in the corpus cavernosum increase, it binds to cGMP receptors resulting in an increased flow of cGMP. This whole process leads to the relaxation of the smooth muscles of the intimal cushions of the helicine arteries. As the arteries relax, they allow more blood to flow in the spongy tissues of the penis hence causing a rigid erection.

Malegra-50 is an effective therapy for the treatment of erectile dysfunction in men. The sildenafil present can enhance the blood flow to the penis thereby increasing the rigidness and firmness of an erection. The effects of Malegra-50 lasts for about 4-6 hours which ensures a long-term remedy for erectile dysfunction. Malegra can treat erectile dysfunction completely, while doses taken according to mood does not have a long lasting effect.

Malegra-50 tablets are best suited if taken by a sexually aroused man 25-30 minutes prior to an expected sexual intercourse. It is advised to consume one tablet per day and not to exceed this limit. The effect of a single dose of this medicine stays for about five to six hours. In some cases, the effects may last longer i.e. up to ten hours.

SIDE EFFECTS:

The majority of them are the same common seen when a person uses sildenafil citrate. This includes flushing of the skin, nausea, Gastrointestinal stress and a feeling of light-headedness. Patients might observe a swelling in the ankles and feet in some cases while they may find difficulty in sleeping in some cases as well. In some men, it may lead to some alarming conditions like losing the sense of hearing. In dose related problems, the persons might achieve prolonged, unwanted and rather painful erections. They might feel this pain in other parts of the body like chest, jaw and left arm.

DRUG INTERACTIONS:

People taking protease inhibitors must use Malegra-50 with care as protease inhibitors, taken for HIV, can inhibit the metabolism of sildenafil leading to increased effects and side effects of sildenafil. Many other drugs can cause interaction with Malegra including the popular antibiotic, Erythromycin and the H2 antagonist Cimetidine, taken for the treatment of peptic ulcers. It is recommended that one does not take Malegra-50 and an alpha-blocker at the same time as this drug combination can lead to lowering of blood pressure to very serious levels. Although no cases have been seen relating this fact, but care is necessary. Malegra is also notorious for its interaction with the nitrates as both drugs when taken simultaneously can cause hypotension.

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