The cumulative dose of oral steroids is associated with increased blood pressure

A new study by CMAJ (Journal of the Canadian Medical Association) found that for patients with chronic inflammatory diseases, the cumulative dose of oral steroids is associated with increased hypertension (blood pressure) of these drugs taken regularly.

Dr. Mar Pujades-Rodriguez of the Leeds Institute of Health Sciences at the University of Leeds said: “The cumulative effect of oral steroid doses on hypertension is huge. Considering that these are commonly prescribed drugs, the associated health burden may be high.”, United Kingdom.

High blood pressure or high blood pressure affects one-fifth of the adults in the world and may have a significant negative impact on health. Previous studies have reported a dose-related response between oral steroids and hypertension, although there is no conclusion.

This study of more than 71,000 patients in 389 general patients in England investigated the relationship between oral glucocorticoid dose and hypertension in patients with chronic inflammatory diseases from 1998 to 2017. The most common underlying diseases include inflammatory bowel disease (35%) and rheumatoid arthritis (28%). The researchers found that in the cohort studied, there were 24 896 cases of new hypertension (accounting for 35%). When the patient reaches the cumulative dose, the incidence of hypertension increases accordingly in a dose-response mode.

The authors recommend that healthcare providers closely monitor the blood pressure of patients who regularly take oral steroid hormones.

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