A mutated virus that can evade nucleic acid detection was found in France. Eight patients carrying the mutated novel coronavirus that was first discovered showed typical symptoms of infection, but the nucleic acid test (PCR test) of their nasopharyngeal samples was negative, and the nucleic acid test could not detect the new strain.
Why this mutant novel coronavirus can evade nucleic acid detection?
Yu Chuanhua, a professor of epidemiology and health statistics at Wuhan University, told the Health Times: “The new strain carries a total of nine mutations in the S protein and other regions of the virus, so it is impossible to identify two possible cases.
First, the amount of infected virus is not enough to detect or has entered the lungs, resulting in a false negative;
Or it could be that the test is negative or there could be too many mutations to detect.”
The French Directorate General of Health issued a notice
A new variant novel Coronavirus has been discovered at a hospital in the Almor-coeur region of Brittany, France, announced the Directorate General of Health in France.
On February 22nd a cluster of infections was found in a business in Brittany.
Three weeks later, Lani Hospital confirmed 79 patients in the cluster, including eight who carried the novel coronavirus variant, which was first identified.
The 8 patients were negative for nucleic acid tests (PCR) of nasopharyngeal samples, although they had typical symptoms of infection.
Subsequently, after further genetic testing by Pasteur Institute, a new mutant novel coronavirus was found in the sample, and the S protein of the new mutant strain carried 9 mutations in total and other virus regions.
Based on preliminary data, French health authorities have not yet been able to determine whether the new mutant strain is more contagious or will cause more severe infections.
French health authorities are investigating to assess the transmission and severity of the new strain and have reported it to the World Health Organization (WHO).
“COVID-19 is a single-stranded RNA virus, which is more mutable than normal DNA viruses,” Yu told Health Times.
Novel coronavirus infection after the symptoms itself is more complex, and the person’s age, physical conditions, combined with basic diseases and other factors related.”
If the new variant escapes detection, Yu notes, it could spread to other areas without being detected.
Geneticists and endocrinologist at the lille medical center Philip frolg el said in an interview with the French news radio, to determine the variation will be found coronavirus is more contagious and lethal takes longer, today also can’t Brittany found that under the light of strains in its nucleic acid testing is used to inspect a surprise, this need for specialized research.
The novel Coronavirus mutant found in Brittany should be treated with caution.
Yu Chuanhua told Health Times: “Viral mutations have always existed, but they will have some impact on vaccine development.
Vaccine development based on the original strain may not be able to effectively cover the impact of the new strain, so the genetic variation of the new strain should be fully taken into account in vaccine development to avoid the failure of the final vaccine to cover the new mutant strain.”
So COVID-19 needs to be prepared for a longer time.
Yu Chuanhua reminded that the current COVID-19 epidemic situation abroad is still in the state of large-scale epidemic, can not be paralyzed.
In general, any confirmed cases or asymptomatic infections found among people entering the country are unlikely to enter the general community, and the public should not panic.
However, people should still wear masks, wash their hands frequently, ventilate frequently, gather less, and do personal protection consciously.