The cumulative dose of oral steroids is associated with increased blood pressure

A new study by CMAJ (Journal of the Canadian Medical Association) found that for patients with chronic inflammatory diseases, the cumulative dose of oral steroids is associated with increased hypertension (blood pressure) of these drugs taken regularly.

Dr. Mar Pujades-Rodriguez of the Leeds Institute of Health Sciences at the University of Leeds said: “The cumulative effect of oral steroid doses on hypertension is huge. Considering that these are commonly prescribed drugs, the associated health burden may be high.”, United Kingdom.

High blood pressure or high blood pressure affects one-fifth of the adults in the world and may have a significant negative impact on health. Previous studies have reported a dose-related response between oral steroids and hypertension, although there is no conclusion.

This study of more than 71,000 patients in 389 general patients in England investigated the relationship between oral glucocorticoid dose and hypertension in patients with chronic inflammatory diseases from 1998 to 2017. The most common underlying diseases include inflammatory bowel disease (35%) and rheumatoid arthritis (28%). The researchers found that in the cohort studied, there were 24 896 cases of new hypertension (accounting for 35%). When the patient reaches the cumulative dose, the incidence of hypertension increases accordingly in a dose-response mode.

The authors recommend that healthcare providers closely monitor the blood pressure of patients who regularly take oral steroid hormones.

Problems with growth hormone secretion, affecting children’s growth

The lack of growth hormone in the human body will affect height growth, especially when the child grows tall, if there is insufficient growth hormone secretion, it will affect the child’s growth, so pay attention to regulating the growth hormone secretion level in the body, then, let us understand Will insufficient growth hormone secretion affect children’s height?

The child is not good for growth hormone secretion problems, affecting the child’s growth
Seventy to eighty percent of human height is caused by genetic factors. Generally speaking, his parents can’t be short in height. However, there is a case where when a child lacks growth hormone, the child’s growth rate becomes slow. Although there is no problem in intelligence, but in terms of height, as the age increases, the growth rate is much slower than that of children of the same age Finally, it leads to short stature.

This dwarf is uniform, has no special face, and has no chromosomal abnormalities (because congenital ovarian dysplasia will lead to a short girl’s stature. This disease chromosome is different from ordinary people. At the same time, there are special physical symptoms, like What is short neck, elbow valgus, low posterior hairline, etc.).

Therefore, the growth hormone deficiency in children has the characteristic features of the disease and the disease that needs to be identified. Therefore, through detailed diagnosis, this disease is not prone to misdiagnosis or missed diagnosis.

Through the introduction, growth hormone deficiency will affect the growth of the child’s height, so you must understand the growth hormone secretion level in the child’s body, if there is a growth hormone secretion problem, it is best to adjust as soon as possible, otherwise it will not only affect the child’s height growth, but also Will adversely affect the child’s life.

Don’t let the kids stay up late

The pandemic is spreading, and most students have not yet started school. Because of less stress in the class, many children start to sleep late. They often stay up late at 12 o’clock at night, and sleep lazy the next day. In this case, parents often stay up late, so it is not surprising that the habit of staying up late happens to children.

What are the hazards of staying up late?

  • 1, Too late to sleep, the child is not tall

After a person is asleep, it is the peak period of growth hormone secretion. If the child stays up for a long time, the circadian clock is disordered, which will affect the secretion of auxin and affect the child’s height. When the child goes to bed early and sleeps soundly, the secretion of natural auxin is more stable and the child grows faster.

2, too late to sleep, the child’s temper will deteriorate

Many children feel depressed, easily irritable, and lose their temper during the day. This is because they haven’t had a good rest at night.

Adequate and good sleep has the ability to repair emotions, especially children who are not under stress now, but also need to restore energy, calm emotions through high-quality sleep. More importantly, do n’t let your child fall asleep with depression, anxiety and anger. Negative emotions will greatly affect your child ’s sleep quality.

  • 3, Sleeping too late, children with low immunity are easy to get sick

Staying up late violates the body’s normal metabolism and also affects the absorption of nutrients. Children who stay up late for a long time have greatly reduced immunity and poor physique, and often get sick easily.

Messi: When I was a kid, I had growth hormone disorders ,Hormone therapy every day

Argentine star Messi revealed that he suffered growth hormone confusion when he was young and needed to inject hormones every night.

The Daily Mail said that Messi ’s condition was also called idiopathic short stature, so he injected hormones into his thighs every night. He told TVAmerica: “I inject hormones into my thighs every night, and I started when I was 12 years old. I am not too impressed with this matter.”

“Before I learned to inject myself, my parents started injecting me when I was 8. This is a small needle and it doesn’t hurt. It was an ordinary thing for me at the time.”

Injecting hormones also brought huge expenses. Messi ’s parents spent £ 1,000 a month until his first club Newell old boy offered to pay for him. In 2001, Messi, who was only 13 years old, joined Barcelona. Barcelona paid all the treatment costs for Messi until he completed the injection course in 2002.

“Joining Barcelona is not difficult for me. I quickly adapted, but my family was not. My siblings came home. My father and I stayed alone, and he asked me” What should we do? ” Say I want to stay. “

appearance suddenly became ugly and hands and feet became thicker, which may be related to pituitary tumors!

Recently, I saw several news reports and shared them with you. I hope you can be alert to this situation!

News 1:

The 42-year-old Ms. Liu found herself ugly in the past six months, her nose became wider, her face wider and her feet larger. She thought she was naturally aging, but she didn’t pay much attention to it, but this change became more and more obvious. After going to the hospital for examination, she realized that it was all because of a pituitary tumor in her head.

News 2:

For more than a year, Mr. Lin, 36 years old, felt that his appearance became more and more ugly, with protruding jaws, swollen lips, and rough skin. He used to wear shoes of size 40 and now wear size 45, and his snoring sound increased. A week ago, I learned after the hospital examination that the cause of his series of changes was a pituitary tumor in the brain. At present, the doctor has removed the pituitary tumor from the nasal cavity through minimally invasive surgery. After a period of symptomatic treatment, he may restore his previous appearance.

Attentive friends must have discovered that the face suddenly becomes ugly, the hands and feet become thicker, and the skin is rough … These symptoms are all caused by pituitary tumors! ! ! In fact, some people will have such a situation in life, but because there is no concept of the symptoms and harm of pituitary tumors, the best treatment time is missed. Let’s take a look at one type of pituitary tumor-growth hormone secretory pituitary tumor.

What is growth hormone secretory pituitary tumor?

There are many types of pituitary tumors. We have also talked about some different types of pituitary tumors and symptoms before.

The growth hormone-secreting pituitary tumors we are going to talk about today have a higher incidence, accounting for the third place in all pituitary tumors, second only to non-functional pituitary tumors and prolactin-secreting pituitary tumors.

Growth hormone-secreting pituitary tumors are mainly manifested as acromegaly and gigantism, simple gigantism is rare, and acromegaly is secondary to more than half of adulthood. The two patients in the above news are all manifestations of acromegaly.

Why do growth hormone-secreting pituitary tumors cause people to become ugly and have thick hands and feet?

Growth hormone-secreting pituitary tumors cause excessive growth hormone (GH) production in the body. What is growth hormone? It is a single peptide chain protein hormone secreted by eosinophils in the anterior pituitary gland. It is a growth regulator with a wide range of physiological functions.

Excessive long-term growth hormone secretion will lead to abnormal hypertrophy of body type and internal organs, accompanied by abnormal physiological functions. In adolescence, adolescents may present with gigantism, and in adults, acromegaly.

Patients with distal limb hypertrophy caused by growth hormone-secreting pituitary tumors will not only have enlarged hands, feet, nose, lips, wide head and face, high cheekbones, but also hoarse voices, sleep snoring, etc. Patients also have tongue and throat soft tissues It will then become hypertrophic, especially when sleeping at night, it is easy to cause breathing problems.

In addition, the incidence of malignant tumors such as pituitary tumor compression symptoms, diabetes, hypertension, cardiovascular and cerebrovascular diseases, respiratory diseases, and colon cancer will also increase. These metabolic disorders and complications seriously affect the health and quality of life of patients.

How to judge whether your condition is related to acromegaly?

Generally, I can judge based on some unique signs. If in recent years, your shoe size has become larger, your face has changed, your cheekbones have protruded, your forehead has become wider, your voice has become lower, your fingers have become thicker, and your skin has roughened, you can rule out whether you have acromegaly disease.

And more than 95% of patients with acromegaly are caused by growth hormone-secreting pituitary tumors, so the above symptoms should go to the regular hospital neurosurgery. However, because many patients have no other discomforts in the early stage when acromegaly symptoms appear, many people do not treat it as a disease, which delays treatment. Many patients with acromegaly in China have not been diagnosed and have not received treatment. This is mainly because people do n’t understand the disease, they do n’t pay attention to it after symptoms appear, and some people think that face ugliness is not a disease until serious complications such as vision loss, heart disease, cerebrovascular disease, diabetic breathing It is a pity that systemic diseases only came to the clinic and missed the opportunity for early diagnosis and treatment.

How to treat a pituitary tumor with growth hormone secretion?

The purpose of the treatment of growth hormone secreting pituitary tumor is to reduce the level of growth hormone in the blood to normal and reduce the size of the tumor. After successful treatment, many acromegaly symptoms and functions will be reversed or improved (except for the bone changes that have occurred and fixed). The treatment methods include surgery, medication and radiation therapy.

Most growth hormone-secreting pituitary tumors are preferably surgically removed. At present, the most commonly used and patient-welcome is the minimally invasive surgery through the transsphenoidal approach assisted by neuroendoscopy, just like the patient in News 2 above. This type of surgery does not require craniotomy, and uses neuroendoscopy technology to directly reach the site where we need to operate from the nostril, leaving the other parts of the pituitary intact, more accurate, safer, and less postoperative complications.

Introduction to Neurosurgery

The Affiliated Hospital of Northwest University · The Third Surgery Hospital of Xi’an City features “Minimally invasive surgery for craniocerebral spinal cord trauma and tumors, minimally invasive interventional surgery for cerebral and spinal vascular diseases and comprehensive treatment of functional neurosurgical diseases” “Green channel” for the treatment of acute cerebrovascular disease and craniocerebral trauma. There are 50 beds and 19 ICU in the center. ICU has the most advanced detection, monitoring equipment and life support system in the world. The department has become a comprehensive neurosurgery integrating clinical, scientific research, teaching, functional rehabilitation and encephalopathy prevention.